Connective tissue diseases encompass a group of autoimmune disorders that affect the skin, joints, and other organs, often requiring coordinated care between dermatology and rheumatology specialists. Conditions such as lupus, dermatomyositis, and scleroderma frequently manifest with skin-related symptoms like rashes, ulcers, or hardening of the skin, which can provide crucial clues for diagnosis. These diseases are complex and can involve systemic complications, making a multidisciplinary approach essential for effective management. Dermatology-rheumatology collaboration allows for comprehensive care, combining expertise in skin health with an understanding of systemic autoimmune processes to develop personalized treatment plans that address both the skin and underlying disease.
Connective Tissue Disease / Dermatology-Rheumatology
Understanding Connective Tissue Diseases
Inherited connective tissue disease occurs when there is a mutation in one of your genes, causing damage to the structure of your skin. Autoimmune connective tissue disease occurs when the cells in your body mistakenly attack your connective tissue. Autoimmune connective tissue disease is often linked to previously existing autoimmune disorders.
Examples of connective tissue disease that affect the skin
Scleroderma
An autoimmune connective tissue disease that causes a build up of scar tissue on the skin. Localized scleroderma only affects the skin and will not affect internal organs. Systemic scleroderma also causes a build up of scar tissue on major internal organs and can lead to organ damage.
Epidermolysis bullosa
A genetic or autoimmune connective tissue disease that causes the skin to become very delicate. The skin will become fragile, easily tearing or blistering at the slightest touch.
Systemic lupus erythematosus autoimmune (SLE or lupus)
An autoimmune connective tissue disease that causes inflammation of the skin. People diagnosed with lupus may notice a rash on their cheeks and nose. Lupus also causes inflammation of the joints and organs.
Dermatomyositis
An autoimmune connective tissue disease that causes a skin rash and muscle weakness. The skin rash may appear violet colored and will develop on the face and in joint areas. Muscle weakness will follow and can worsen over time.
